Abstract
Although immunoglobulin (Ig) A is commonly recognized as the most prevalent antibody subclass at mucosal sites with an important role in mucosal defense, its potential as a therapeutic monoclonal antibody is less well known. However, IgA has multifaceted anti-, non-, and pro-inflammatory functions that can be exploited for different immunotherapeutical strategies, which will be the focus of this review.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibodies, Monoclonal / chemistry
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Antibodies, Monoclonal / immunology
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Antibodies, Monoclonal / therapeutic use*
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Humans
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Immunity, Mucosal
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Immunoglobulin A / chemistry
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Immunoglobulin A / immunology
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Immunoglobulin A / therapeutic use*
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Immunotherapy / methods
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Infections / therapy*
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Models, Molecular
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Neoplasms / therapy*
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Receptors, IgE / immunology*
Substances
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Antibodies, Monoclonal
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Immunoglobulin A
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Receptors, IgE