Abstract
A novel route to (±)-platencin is reported, in which the highly stereoselective alkylative quaternization of a cyclohexenone scaffold via 1,4-diastereoinduction and two radical carbon-carbon bond-forming reactions that involve titanium(III)-mediated cyclization and stannyl-radical-mediated skeletal rearrangement are utilized.
© 2011 American Chemical Society
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminophenols / chemical synthesis*
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Aminophenols / chemistry
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Cyclization
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Molecular Structure
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Polycyclic Compounds / chemical synthesis*
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Polycyclic Compounds / chemistry
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Stereoisomerism
Substances
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Aminophenols
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Anti-Bacterial Agents
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Polycyclic Compounds
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platencin