Abstract
Antiseptic gelatin sponges with kanamycin and gentamicin, which were studied in experiments on animals and used in the clinic, are a reliable measure for the prevention of suppuration in craniocerebral surgery in planned operations and in combination with debridement in penetrating injury of the skull and brain. For therapeutic purposes, local application of the agents is effective in focal suppurative processes in the skull and brain after surgical debridement of the purulent focus (abscess of the brain, osteomyelitis of the skull, etc.).
MeSH terms
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Animals
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Antisepsis / methods
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Brain / surgery*
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Brain Diseases / etiology
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Brain Diseases / prevention & control*
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Brain Injuries / complications
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Brain Injuries / surgery
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Delayed-Action Preparations
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Dogs
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Drug Evaluation
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Drug Evaluation, Preclinical
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Gelatin
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Gentamicins / administration & dosage*
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Humans
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Kanamycin / administration & dosage*
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Rabbits
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Staphylococcal Infections / etiology
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Staphylococcal Infections / prevention & control*
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Surgical Wound Infection / etiology
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Surgical Wound Infection / prevention & control*
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Wounds, Nonpenetrating / complications
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Wounds, Nonpenetrating / surgery
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Wounds, Penetrating / complications
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Wounds, Penetrating / surgery
Substances
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Delayed-Action Preparations
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Gentamicins
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Kanamycin
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Gelatin