In vivo cell death mediated by synthetic ion channels

Chem Commun (Camb). 2011 Jul 28;47(28):7977-9. doi: 10.1039/c1cc12933c. Epub 2011 Jun 17.

Abstract

Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biomimetic Materials / administration & dosage
  • Biomimetic Materials / chemistry
  • Biomimetic Materials / pharmacology*
  • Cell Death / drug effects*
  • HEK293 Cells
  • HeLa Cells
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Injections
  • Ion Channels / metabolism*
  • Ion Transport / drug effects
  • Mice

Substances

  • Ion Channels