Development of antitrypanosomal and antiplasmodial nonpeptidic cysteine protease inhibitors based on N-protected-guanidino-furan and -pyrrole building blocks

ChemMedChem. 2011 Sep 5;6(9):1581-6. doi: 10.1002/cmdc.201100189. Epub 2011 Jun 15.

Authors

Sebastian Langolf¹, Uwe Machon, Martin Ehlers, Wilhelm Sicking, Tanja Schirmeister, Christian Büchhold, Christoph Gelhaus, Philip J Rosenthal, Carsten Schmuck

Affiliation

¹ Institute of Organic Chemistry, University of Duisburg-Essen, Universitätstrasse 7, 45141 Essen, Germany.

PMID: 21678556
DOI: 10.1002/cmdc.201100189

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemical synthesis
Antimalarials / chemistry
Antimalarials / pharmacology*
Cysteine Proteinase Inhibitors / chemical synthesis
Cysteine Proteinase Inhibitors / chemistry
Cysteine Proteinase Inhibitors / pharmacology*
Furans / chemistry
Guanidines / chemistry
Humans
Malaria, Falciparum / drug therapy*
Malaria, Falciparum / metabolism
Malaria, Falciparum / pathology
Plasmodium falciparum / drug effects*
Plasmodium falciparum / growth & development
Plasmodium falciparum / metabolism
Pyrroles / chemistry
Structure-Activity Relationship
Trypanocidal Agents / chemical synthesis
Trypanocidal Agents / chemistry
Trypanocidal Agents / pharmacology*
Trypanosoma brucei brucei / drug effects*
Trypanosoma brucei brucei / growth & development
Trypanosoma brucei brucei / metabolism
Trypanosomiasis / drug therapy*
Trypanosomiasis / metabolism
Trypanosomiasis / pathology

Substances

Antimalarials
Cysteine Proteinase Inhibitors
Furans
Guanidines
Pyrroles
Trypanocidal Agents
furan