Abstract
Transition metal complexes bearing amino linked N-heterocyclic carbenes (NHC) were prepared and evaluated for their antiproliferative activities in human cancer cells. The optimum antiproliferative activity, observed for the gold complex 3 in U-87 MG cells, was found to involve S-phase arrest of the cell cycle. The results indicate that 3 induces apoptosis through a p53-bak pathway, a finding that could serve as a new strategy to reduce the resistance of cancer cells to p53-induced apoptosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Apoptosis*
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Cell Line, Tumor
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Coordination Complexes / chemical synthesis*
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology
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Cyclin A / biosynthesis
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Cyclin B / biosynthesis
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Cyclin-Dependent Kinase 2 / biosynthesis
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Drug Screening Assays, Antitumor
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Gold*
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Humans
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry
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Imidazoles / pharmacology
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Methane / analogs & derivatives*
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Methane / chemical synthesis
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Methane / chemistry
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Methane / pharmacology
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Palladium*
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S Phase
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Silver*
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Structure-Activity Relationship
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Tumor Suppressor Protein p53 / physiology
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bcl-2 Homologous Antagonist-Killer Protein / physiology
Substances
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Antineoplastic Agents
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Coordination Complexes
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Cyclin A
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Cyclin B
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Imidazoles
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Tumor Suppressor Protein p53
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bcl-2 Homologous Antagonist-Killer Protein
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carbene
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Silver
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Palladium
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Gold
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Cyclin-Dependent Kinase 2
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Methane