Abstract
Vitrification had a significantly negative impact on the mitochondrial function of bovine oocytes. However, 40 μg/mL cyclosporine pretreatment before vitrification contributed greatly to maintaining mitochondrial membrane potential and adenosine triphosphate content, decreasing reactive oxygen species level, and thereby increasing the developmental ability of vitrified oocytes.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine / analogs & derivatives
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Adenine / pharmacology
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Adenosine Triphosphate / metabolism
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Animals
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Blastocyst / drug effects
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Calcimycin / pharmacology
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Cattle
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Cryopreservation*
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Cyclosporine / pharmacology*
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Embryo Culture Techniques
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Female
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Ionophores / pharmacology
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Membrane Potential, Mitochondrial / drug effects
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Mitochondria / drug effects*
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Mitochondria / metabolism
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Oocytes / drug effects*
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Oocytes / metabolism
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Parthenogenesis / drug effects
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Reactive Oxygen Species / metabolism
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Time Factors
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Vitrification*
Substances
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Ionophores
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Reactive Oxygen Species
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Calcimycin
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N(6),N(6)-dimethyladenine
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Cyclosporine
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Adenosine Triphosphate
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Adenine