Glucosamine hydrochloride functionalized water-soluble conjugated polyfluorene: synthesis, characterization, and interactions with DNA

Qi Chen; Qian-Yi Cheng; Yan-Chao Zhao; Bao-Hang Han

doi:10.1002/marc.200900226

Glucosamine hydrochloride functionalized water-soluble conjugated polyfluorene: synthesis, characterization, and interactions with DNA

Macromol Rapid Commun. 2009 Oct 1;30(19):1651-5. doi: 10.1002/marc.200900226. Epub 2009 Jul 10.

Authors

Qi Chen¹, Qian-Yi Cheng, Yan-Chao Zhao, Bao-Hang Han

Affiliation

¹ National Center for Nanoscience and Technology, Beijing 100190, China.

PMID: 21638433
DOI: 10.1002/marc.200900226

Abstract

Novel glucosamine hydrochloride functionalized water-soluble conjugated polyfluorene was easily synthesized through Cu(I)-catalyzed azide/alkyne "click" ligation and Suzuki coupling polymerization. The water-solubility and biocompatibility of the polymer were improved after grafting glucosamine hydrochloride to the side chains of the conjugated polymer. As a fluorescent model system of chitosan, its interaction with single-stranded DNA was studied by spectrofluorometric titration.