Selective accumulation of hybrid liposomes into adult T-cell leukemia cells along with induction of apoptosis

Yuji Komizu; Mamiko Yukihara; Ryusho Kariya; Koichi Goto; Seiji Okada; Ryuichi Ueoka

doi:10.1016/j.bmcl.2011.05.015

Selective accumulation of hybrid liposomes into adult T-cell leukemia cells along with induction of apoptosis

Bioorg Med Chem Lett. 2011 Jul 1;21(13):3962-5. doi: 10.1016/j.bmcl.2011.05.015. Epub 2011 May 14.

Authors

Yuji Komizu¹, Mamiko Yukihara, Ryusho Kariya, Koichi Goto, Seiji Okada, Ryuichi Ueoka

Affiliation

¹ Division of Applied Life Science, Graduate School of Engineering, Sojo University, Japan.

PMID: 21632245
DOI: 10.1016/j.bmcl.2011.05.015

Abstract

Markedly inhibitory effects of hybrid liposomes (HL-n) composed of 90 mol% L-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of adult T-cell leukemia cells were obtained for the first time. It is noteworthy that HL-n could selectively accumulate into the adult T-cell leukemia cells and induce apoptosis via caspase-3 activation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Carmustine / administration & dosage
Cells, Cultured
Dimyristoylphosphatidylcholine / chemistry
Drug Delivery Systems*
Hexoses / chemistry
Humans
Inhibitory Concentration 50
Leukemia-Lymphoma, Adult T-Cell
Liposomes / administration & dosage*
Liposomes / chemistry
Polysorbates / chemistry

Substances

Hexoses
Liposomes
Polysorbates
sorbitan monolaurate
Carmustine
Dimyristoylphosphatidylcholine