Copper-catalyzed arylation of 1H-perfluoroalkanes

J Am Chem Soc. 2011 Jun 22;133(24):9286-9. doi: 10.1021/ja2041942. Epub 2011 May 31.

Abstract

A general method has been developed for arylation of readily available 1H-perfluoroalkanes. The method employs aryl iodide and 1H-perfluoroalkane reagents, DMPU solvent, TMP(2)Zn base, and a copper chloride/phenanthroline catalyst. Preliminary mechanistic studies are reported.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Fluorocarbons / chemistry*

Substances

  • Alkanes
  • Fluorocarbons
  • Copper