Synthesis, structure and cytotoxicity of 3-C, N, S, Se substituted benzo[b]selenophene derivatives

Eur J Med Chem. 2011 Aug;46(8):3434-43. doi: 10.1016/j.ejmech.2011.05.008. Epub 2011 May 13.

Abstract

Synthesis, molecular structure and cytotoxic activity of a series of 3-C, N, S, Se substituted benzo[b]selenophene derivatives on human fibrosarcoma HT-1080, mouse hepatoma MG-22A, and mouse fibroblasts 3T3 cell lines are described. The correlation between compound LD(50) 3T3 fibroblast cell line and HT-1080 morphology was shown.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acridine Orange / analysis
  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Apoptosis / drug effects
  • Carbon / chemistry
  • Carcinoma, Hepatocellular / drug therapy
  • Carcinoma, Hepatocellular / pathology
  • Cell Line, Tumor
  • Cell Survival / drug effects*
  • Drug Screening Assays, Antitumor
  • Fibroblasts / cytology
  • Fibroblasts / drug effects*
  • Fibrosarcoma / drug therapy
  • Fibrosarcoma / pathology
  • Humans
  • Inhibitory Concentration 50
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / pathology
  • Mice
  • Microscopy, Fluorescence
  • Models, Molecular
  • Nitrogen / chemistry
  • Selenium / chemistry*
  • Structure-Activity Relationship
  • Sulfur / chemistry
  • Thiophenes / chemical synthesis*
  • Thiophenes / pharmacology

Substances

  • Antineoplastic Agents
  • Thiophenes
  • benzothiophene
  • Sulfur
  • Carbon
  • Acridine Orange
  • Selenium
  • Nitrogen