Abstract
In rats unilaterally lesioned with 6-hydroxydopamine, the D-1 agonist SKF 38393 (3 mg/kg SC) induced contralateral turning only after priming with a dopaminergic agonist such as apomorphine. Administration of the N-methyl-D-aspartate receptor antagonist (+) MK 801 (0.1 mg/kg IP) 15 min before apomorphine (0.1 mg/kg SC) prevented the ability of apomorphine to act as a primer while potentiating its acute contralateral turning effects. The inactive isomer (-) MK 801 was without effect. The results indicate that the N-methyl-D-aspartate receptor exerts a permissive role on priming.
MeSH terms
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / antagonists & inhibitors*
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Animals
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Apomorphine / pharmacology
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / physiology
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Dibenzocycloheptenes / pharmacology*
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Dizocilpine Maleate
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Hydroxydopamines / pharmacology
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Male
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N-Methylaspartate
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Oxidopamine
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Rats
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Rats, Inbred Strains
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Stereoisomerism
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Stereotyped Behavior / drug effects*
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Sympathectomy, Chemical
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Synaptic Transmission / drug effects*
Substances
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Dibenzocycloheptenes
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Hydroxydopamines
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Aspartic Acid
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N-Methylaspartate
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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Dizocilpine Maleate
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Oxidopamine
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Apomorphine