Phylogenetic and functional analysis of Aspergillus fumigatus MGTC, a fungal protein homologous to a bacterial virulence factor

Appl Environ Microbiol. 2011 Jul;77(13):4700-3. doi: 10.1128/AEM.00243-11. Epub 2011 May 20.

Abstract

MgtC is important for the survival of several bacterial pathogens in macrophages and for growth under magnesium limitation. Among eukaryotes, a gene homologous to mgtC was found only in the pathogenic fungus Aspergillus fumigatus. Our data show that the A. fumigatus MgtC (AfuMgtC) protein does not have the same function as the bacterial MgtC proteins.

MeSH terms

  • Amino Acid Sequence
  • Aspergillus fumigatus / enzymology*
  • Aspergillus fumigatus / genetics*
  • Aspergillus fumigatus / growth & development
  • Cation Transport Proteins / genetics*
  • Cation Transport Proteins / metabolism*
  • Cluster Analysis
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Magnesium / metabolism*
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Homology, Amino Acid
  • Virulence
  • Virulence Factors / genetics*
  • Virulence Factors / metabolism*

Substances

  • Cation Transport Proteins
  • Fungal Proteins
  • Virulence Factors
  • Magnesium