In vitro human tissue models--moving towards personalized regenerative medicine

Katja Schenke-Layland; Robert M Nerem

doi:10.1016/j.addr.2011.05.001

In vitro human tissue models--moving towards personalized regenerative medicine

Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):195-6. doi: 10.1016/j.addr.2011.05.001. Epub 2011 May 18.

Authors

Katja Schenke-Layland¹, Robert M Nerem

Affiliation

¹ Department of Cell and Tissue Engineering, Fraunhofer-Institute for Interfacial Engineering and Biotechnology (IGB), Nobelstrasse 12, 70569 Stuttgart, Germany. katja.schenke-layland@igb.fraunhofer.de

PMID: 21600252
DOI: 10.1016/j.addr.2011.05.001

Abstract

The field of tissue engineering is a rapidly growing interdisciplinary field within regenerative medicine involving biology, chemistry, physics, engineering and medical sciences, which focuses on the fabrication of replacement tissues and organs. Another major focus of tissue engineering is the creation of ex vivo-manufactured multi-organ test systems, in order to explore fundamental questions of cell, matrix and developmental biology. These ex-vivo manufactured systems can also be used to study drug delivery dynamics.

MeSH terms

Animals
Drug Delivery Systems
Humans
Models, Biological
Organ Culture Techniques / methods
Precision Medicine / methods*
Regenerative Medicine / methods*
Tissue Engineering / methods*