Liver resection is the only potentially curative treatment option of patients with colorectal cancer metastases. However, at the time of diagnosis, most patients have irresectable tumors. Preoperative chemotherapy and portal vein embolization may lead to downsizing of initially irresectable colorectal cancer metastases, located in one lobe of the liver. Although, in group of patients with bilobar involvement such neoadjuvant therapy does not enable performance of radical operation. Irresectability of these tumors is mainly due to a functionally insufficient amount of future, postoperative remnant liver volume. Hereby, we present a novel treatment strategy of two-stage liver resection with portal branch ligation and inter and postoperative chemotherapy, we discuss the indications for this procedure in view of the presented cases and we review the literature on the treatment of patients with initially irresectable, bilobar liver metastases from colorectal cancer.