Design and synthesis of a bombesin peptide-conjugated tripodal phosphino dithioether ligand topology for the stabilization of the fac-[M(CO)3]+ core (M=(99 m)Tc or Re)

Inorg Chem. 2011 Jul 4;50(13):6210-9. doi: 10.1021/ic200491z. Epub 2011 May 18.

Abstract

A new tumor-seeking tridentate topology consisting of a phosphino dithioether ((HOCH(2))(2)PCH(2)CH(2)S(CH(2))(n)CH(2)SR; PS(2)) ligand framework for the production of kinetically inert and in vivo stable facial [(99m)Tc(CO)(3)(PS(2))](+) or [Re(CO)(3)(PS(2))](+) is described. The X-ray crystal structure of fac-Re(CO)(3)(PS(2))PF(6) is reported. The bioconjugation strategies for incorporating bombesin (BBN) peptides on to the PS(2) tripodal framework and, thereby, de novo designing of GRP receptor-seeking Tc(PS(2)-BBN)(CO)(3) are developed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bombesin / chemistry*
  • Carbon Monoxide / chemistry*
  • Crystallography, X-Ray
  • Kinetics
  • Ligands
  • Models, Molecular
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry
  • Rhenium / chemistry*
  • Stereoisomerism
  • Sulfhydryl Compounds / chemistry*
  • Technetium / chemistry*

Substances

  • Ligands
  • Organometallic Compounds
  • Sulfhydryl Compounds
  • Rhenium
  • Technetium
  • Carbon Monoxide
  • Bombesin