Gold Nanoparticles Functionalized by a Dextran-Based pH- and Temperature-Sensitive Polymer

Weipeng Lv; Shuoqi Liu; Xiaobin Fan; Shulan Wang; Guoliang Zhang; Fengbao Zhang

doi:10.1002/marc.200900624

Gold Nanoparticles Functionalized by a Dextran-Based pH- and Temperature-Sensitive Polymer

Macromol Rapid Commun. 2010 Mar 2;31(5):454-8. doi: 10.1002/marc.200900624. Epub 2009 Dec 3.

Authors

Weipeng Lv¹, Shuoqi Liu, Xiaobin Fan, Shulan Wang, Guoliang Zhang, Fengbao Zhang

Affiliation

¹ School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, P. R. China.

PMID: 21590926
DOI: 10.1002/marc.200900624

Abstract

A dextran-based dual-sensitive polymer is employed to endow gold nanoparticles with stability and pH- and temperature-sensitivity. The dual-sensitive polymer is prepared by RAFT polymerization of N-isopropylacrylamide from trithiocarbonate groups linked to dextran and succinoylation of dextran after polymerization. The functionalized nanoparticles show excellent stability under various conditions and can be stored in powder-form. UV and DLS measurements confirm that the temperature-induced optical changes and aggregation behaviors of the particles are strongly dependent on pH.