1,2,3,4-Tetra-hydro-1,4-methano-naphthalene-2,3-diol

Acta Crystallogr Sect E Struct Rep Online. 2008 Dec 10;65(Pt 1):o79. doi: 10.1107/S1600536808041068.

Abstract

The title compound, C(11)H(12)O(2), is an inter-mediate in the synthesis of Varenicline, a nicotinic receptor partial agonist used to treat smoking addiction. In the crystal structure, there is an intra-molecular O-H⋯O hydrogen bond that generates an S(5) ring motif. Inter-molecular O-H⋯O hydrogen bonds form centrosymmetric dimers and also link these dimers into chains along the a axis.