Mechanism and evolution of the uncoupling protein of brown adipose tissue

Trends Biochem Sci. 1990 Mar;15(3):108-12. doi: 10.1016/0968-0004(90)90194-g.

Abstract

The uncoupling protein found in mitochondria from thermogenic brown adipose tissue is structurally very similar to two other mitochondrial carrier proteins transporting ADP/ATP and phosphate, respectively. Similarities are also seen with the mechanism of these carriers, which are part of a family of H+/OH(-)-substrate anion co-transporters, further strengthening the evidence that the uncoupling protein has evolved from this family of mitochondrial carrier proteins.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Adipose Tissue, Brown / metabolism*
  • Amino Acid Sequence
  • Animals
  • Biological Evolution*
  • Carrier Proteins / classification
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Hydroxides
  • Ion Channels
  • Membrane Proteins / classification
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism
  • Mitochondrial Proteins
  • Molecular Sequence Data
  • Protein Conformation
  • Protons
  • Uncoupling Protein 1

Substances

  • Carrier Proteins
  • Hydroxides
  • Ion Channels
  • Membrane Proteins
  • Mitochondrial Proteins
  • Protons
  • Uncoupling Protein 1
  • hydroxide ion