In the title complex, {[Ag(2)Nd(C(6)H(4)NO(2))(4)(H(2)O)(2)]NO(3)·H(2)O}(n), the Nd(III) ion is coordinated by eight O atoms from six isonicotinate ligands and two water mol-ecules in a distorted square anti-prismatic geometry. Each Ag(I) ion is coordinated by two N atoms from two different isonicotinate ligands. The crystal structure exhibits a two-dimensional heterometallic polymeric layer. O-H⋯O hydrogen bonds involving the coordinated and uncoordinated water mol-ecules and intra-layer π-π inter-actions between the pyridine rings [centroid-centroid distances = 3.571 (2) and 3.569 (2) Å] are observed. Each layer inter-acts with two neighboring ones via Ag⋯O(H(2)O) contacts and inter-layer π-π inter-actions [centroid-centroid distances = 3.479 (3) to 3.530 (3) Å], leading to a three-dimensional supra-molecular network.