[Clostridium difficile enteritis]

Gastroenterol Hepatol. 2011 Oct;34(8):539-45. doi: 10.1016/j.gastrohep.2011.03.005. Epub 2011 May 14.
[Article in Spanish]

Abstract

Introduction: Clostridium difficile infection of the small intestine is infrequent.

Method: We present the first case of C. difficile enteritis (CDE) diagnosed in Spain and provide a review of the literature.

Results: A 30-year-old man underwent surgery for recurrence of a retroperitoneal germ cell tumor. Seven days later the patient developed vomiting, diarrhea and, finally, intestinal obstruction due to pseudomembranes caused by CDE. Only 57 cases of CDE have been reported in the literature. The mean age was 52±17 years with a range of 18 to 86 years. Twenty-nine patients (50%) had inflammatory bowel disease. Forty-seven (81%) had a history of colon or small intestine surgery. Mortality was higher in older patients and in those without inflammatory bowel disease.

Conclusion: CDE is characterized by high severity and mortality.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bleomycin / administration & dosage
  • Bleomycin / adverse effects
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects
  • Clostridioides difficile / isolation & purification*
  • Combined Modality Therapy
  • Enteritis / diagnosis
  • Enteritis / drug therapy
  • Enteritis / microbiology*
  • Enteritis / surgery
  • Enterocolitis, Pseudomembranous / diagnosis*
  • Enterocolitis, Pseudomembranous / epidemiology
  • Enterocolitis, Pseudomembranous / microbiology
  • Enterocolitis, Pseudomembranous / surgery
  • Etoposide / administration & dosage
  • Etoposide / adverse effects
  • Gastrostomy
  • Humans
  • Ileostomy
  • Intestinal Obstruction / etiology
  • Male
  • Multiple Organ Failure / etiology
  • Neoplasms, Germ Cell and Embryonal / drug therapy
  • Neoplasms, Germ Cell and Embryonal / secondary
  • Neoplasms, Germ Cell and Embryonal / surgery
  • Nephrectomy
  • Opportunistic Infections / diagnosis
  • Opportunistic Infections / drug therapy
  • Opportunistic Infections / microbiology*
  • Opportunistic Infections / surgery
  • Orchiectomy
  • Postoperative Complications / diagnosis
  • Postoperative Complications / drug therapy
  • Postoperative Complications / microbiology*
  • Spain / epidemiology
  • Superinfection
  • Testicular Neoplasms / drug therapy
  • Testicular Neoplasms / pathology
  • Testicular Neoplasms / surgery

Substances

  • Anti-Bacterial Agents
  • Bleomycin
  • Etoposide
  • Cisplatin