Abstract
Structure stability/activity relationships (SXR) of a new class of N,N-dichloroamine compounds were explored to improve antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans while maintaining aqueous solution stability. This study identified a new class of solution-stable and topical antimicrobial agents. These agents are sulfone-stabilized and possess either a quaternary ammonium or sulfonate appendages as a water solubilizing group. Several unique challenges were confronted in the synthesis of these novel compounds which are highlighted in the discussion.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology
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Chloramines / chemical synthesis*
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Chloramines / chemistry
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Chloramines / pharmacology
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Drug Stability
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Escherichia coli / drug effects
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Molecular Structure
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Staphylococcus aureus / drug effects
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Structure-Activity Relationship
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Sulfones / chemical synthesis*
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Sulfones / chemistry
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Sulfones / pharmacology
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Water / chemistry*
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Chloramines
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Sulfones
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Water