Activation and effector functions of human RORC+ innate lymphoid cells

Curr Opin Immunol. 2011 Jun;23(3):361-7. doi: 10.1016/j.coi.2011.03.002. Epub 2011 May 9.

Abstract

Innate lymphoid cells expressing the nuclear hormone receptor RORC have emerged as important players in human mucosal immunity. These cells combine innate modes of activation such as Toll-like receptor signaling with secretion of adaptive effector molecules including IL-2, BAFF and the Th17 cytokines IL-17 and IL-22. This endows these cells with the ability to rapidly respond to changes in cytokine milieu as well as changes in microbial composition and to affect both intestinal homeostasis and activation of adaptive immune cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytokines / biosynthesis
  • Cytokines / immunology
  • Humans
  • Immunity, Innate*
  • Lymphocyte Activation*
  • Lymphocytes / immunology*
  • Lymphocytes / metabolism
  • Nuclear Receptor Subfamily 1, Group F, Member 3 / immunology*
  • Toll-Like Receptors / immunology
  • Toll-Like Receptors / metabolism

Substances

  • Cytokines
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • RORC protein, human
  • Toll-Like Receptors