Abstract
Two new sorbicillinoids, 1 and 2, together with a novel benzofuranone derivative named phialofurone (3), were isolated from a deep-sea sediment-derived fungus, Phialocephala sp. Their structures were established on the basis of spectroscopic data. All compounds displayed cytotoxic effects against P388 (IC(50) values of 11.5±1.4, 0.1±0.1, and 0.2±0.01 μM, resp.) and K562 (IC(50) values of 22.9±0.8, 4.8±0.3 and 22.4±0.9 μM, resp.) cell lines.
Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemistry*
-
Antineoplastic Agents / isolation & purification
-
Antineoplastic Agents / pharmacology*
-
Ascomycota / chemistry*
-
Benzofurans / chemistry*
-
Benzofurans / isolation & purification
-
Benzofurans / pharmacology*
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Cyclohexanones / chemistry*
-
Cyclohexanones / isolation & purification
-
Cyclohexanones / pharmacology*
-
Drug Screening Assays, Antitumor
-
Humans
-
Neoplasms / drug therapy
Substances
-
Antineoplastic Agents
-
Benzofurans
-
Cyclohexanones