Abstract
In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC₅₀ value of 1.5 μg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 μg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product.
Keywords:
Indonesian marine fungi; algicolous fungi; antifungal; bioactive compounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / administration & dosage
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology*
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Biological Products / administration & dosage
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Biological Products / isolation & purification
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Biological Products / pharmacology
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Cell Line, Tumor
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Culture Media
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Fishes
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Fresh Water
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Fungi / isolation & purification
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Fungi / metabolism*
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Humans
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Indonesia
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Inhibitory Concentration 50
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Rhodophyta / microbiology
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Seawater
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Urinary Bladder Neoplasms / drug therapy
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Urinary Bladder Neoplasms / pathology
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Antineoplastic Agents
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Biological Products
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Culture Media