[Antagonists of interleukin-6 (tocilizumab), in adult refractory still disease]

Abstract

Introduction: The pathogenesis of Still's disease is best elucidated for the better recognition of the involvement of Many pro-inflammatory cytokines in the genesis of this condition. Publications have reported the contribution beneficial for certain biotherapeutics, such as anti-TNFa, the anti-CD20 or antagonists of interleukine1 (IL-1) tested successfully in the treatment of systemic Juvenile idiopathic arthritis (Still's disease the child), the tocilizumab is a humanized monoclonal antibody directed against the receptor for interleukin-6 and is beginning to be reported as effective in some refractory cases of Still's disease in adults.

Patients: We report two young patients with Still's disease in adults with refractory early and prolonged remission after the first infusion tocilizumab.

Conclusion: The tocilizumab can be used in patients MSA with refractory after failure or intolerance conventional treatments.