Structure inducing ionic liquids-enhancement of alpha helicity in the Abeta(1-40) peptide from Alzheimer's disease

Natalie Debeljuh; Colin J Barrow; Luke Henderson; Nolene Byrne

doi:10.1039/c1cc10377f

Structure inducing ionic liquids-enhancement of alpha helicity in the Abeta(1-40) peptide from Alzheimer's disease

Chem Commun (Camb). 2011 Jun 14;47(22):6371-3. doi: 10.1039/c1cc10377f. Epub 2011 May 6.

Authors

Natalie Debeljuh¹, Colin J Barrow, Luke Henderson, Nolene Byrne

Affiliation

¹ Institute for Technology Research and Innovation, Deakin University, Geelong, Vic 3217, Australia.

PMID: 21547327
DOI: 10.1039/c1cc10377f

Abstract

We have studied the impact of ionic liquid solvents on the structure of the Abeta(1-40) peptide from Alzheimer's disease and found that ionic liquid solvents were able to induce a conformational change in the structure of the Abeta(1-40) peptide. This conformational change impacts the self-assembly of the peptide into amyloid fibrils.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / metabolism*
Amyloid beta-Peptides / chemistry*
Amyloid beta-Peptides / metabolism
Circular Dichroism
Humans
Ionic Liquids / chemistry*
Peptide Fragments / chemistry*
Peptide Fragments / metabolism
Protein Folding
Protein Structure, Secondary
Solvents / chemistry

Substances

Amyloid beta-Peptides
Ionic Liquids
Peptide Fragments
Solvents
amyloid beta-protein (1-40)