Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy

Yosuke Amemiya; Yui Furunaga; Keisuke Iida; Masayuki Tera; Kazuo Nagasawa; Kazunori Ikebukuro; Chikashi Nakamura

doi:10.1039/c0cc05781a

Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy

Chem Commun (Camb). 2011 Jul 14;47(26):7485-7. doi: 10.1039/c0cc05781a. Epub 2011 May 5.

Authors

Yosuke Amemiya¹, Yui Furunaga, Keisuke Iida, Masayuki Tera, Kazuo Nagasawa, Kazunori Ikebukuro, Chikashi Nakamura

Affiliation

¹ Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.

PMID: 21547284
DOI: 10.1039/c0cc05781a

Abstract

The force analysis between a macrocyclic hexazole (6OTD) monomer/dimer and telomeric DNA using atomic force microscopy revealed the difference in their binding modes. The 6OTD dimer bound to the G-quadruplex more strongly than the monomer by sandwiching the G-quadruplex.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

G-Quadruplexes*
Humans
Microscopy, Atomic Force*
Oxazoles / metabolism*
Telomere / chemistry*
Telomere / metabolism*

Substances

Oxazoles
telomestatin