Abstract
Investigation of a new collection of the Red Sea sponge Suberea mollis afforded two new brominated arginine-derived alkaloids, subereamines A (1) and B (2), a new brominated phenolic compound, subereaphenol D (3), and the known compounds dichloroverongiaquinol (4), aerothionin (5), and purealdin L (6). The structures of the isolated compounds were assigned using one- and two-dimensional NMR spectra and HRFABMS data. The absolute configurations of subereamines A (1) and B (2) were determined by acid hydrolysis followed by chiral-phase LC-MS. The antimicrobial and antioxidant activities of the isolated compounds have been evaluated. Dichloroverongiaquinol and subereaphenol D displayed significant antimicrobial activity. Using the DPPH TLC autographic rapid screen for free radical scavenging effects, subereaphenol D displayed a significant antioxidant effect. In addition, the cytotoxic activities of the isolated compounds were investigated.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology
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Arginine / analogs & derivatives*
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Arginine / chemistry
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Arginine / isolation & purification
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Arginine / pharmacology
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Biphenyl Compounds / pharmacology
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Hydrocarbons, Brominated / chemistry
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Hydrocarbons, Brominated / isolation & purification*
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Hydrocarbons, Brominated / pharmacology
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Indian Ocean
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Picrates / pharmacology
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Porifera / chemistry*
Substances
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Alkaloids
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Antineoplastic Agents
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Antioxidants
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Biphenyl Compounds
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Hydrocarbons, Brominated
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Picrates
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subereamine A
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subereamine B
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subereaphenol D
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Arginine
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1,1-diphenyl-2-picrylhydrazyl