Metal-containing peptide nucleic acid conjugates

Dalton Trans. 2011 Jul 21;40(27):7061-76. doi: 10.1039/c0dt01706j. Epub 2011 May 3.

Abstract

Peptide Nucleic Acids (PNAs) are non-natural DNA/RNA analogues with favourable physico-chemical properties and promising applications. Discovered nearly 20 years ago, PNAs have recently re-gained quite a lot of attention. In this Perspective article, we discuss the latest advances on the preparation and utilisation of PNA monomers and oligomers containing metal complexes. These metal- conjugates have found applications in various research fields such as in the sequence-specific detection of nucleic acids, in the hydrolysis of nucleic acids and peptides, as radioactive probes or as modulators of PNA·DNA hybrid stability, and last but not least as probes for molecular and cell biology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomimetic Materials / chemical synthesis
  • Biomimetic Materials / chemistry*
  • Biomimetic Materials / metabolism
  • Biosensing Techniques* / methods
  • Catalysis
  • Cell Membrane Permeability
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry*
  • Coordination Complexes / metabolism
  • Cross-Linking Reagents / chemistry
  • DNA / chemistry
  • Deoxyribonucleases / metabolism
  • Humans
  • Models, Molecular
  • Oxidation-Reduction
  • Peptide Hydrolases / metabolism
  • Peptide Nucleic Acids / chemical synthesis
  • Peptide Nucleic Acids / chemistry*
  • Peptide Nucleic Acids / metabolism
  • Ribonucleases / metabolism

Substances

  • Coordination Complexes
  • Cross-Linking Reagents
  • Peptide Nucleic Acids
  • DNA
  • Deoxyribonucleases
  • Ribonucleases
  • Peptide Hydrolases