Synthesis and antitumor activity of novel podophyllotoxin derivatives against multidrug-resistant cancer cells

J Asian Nat Prod Res. 2011 May;13(5):417-24. doi: 10.1080/10286020.2011.568941.

Abstract

Seven novel 4β-N-substituted podophyllotoxin derivatives with indole rings were prepared and evaluated for cytotoxicity against human cancer cell lines HeLa, KB, KBV, K562, and K562/AO2. Most of them demonstrated improved antitumor activity and weak multidrug resistance compared to the drugs currently available.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic* / chemical synthesis
  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Drug Resistance, Multiple / drug effects
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Humans
  • K562 Cells
  • KB Cells
  • Molecular Structure
  • Podophyllotoxin* / analogs & derivatives
  • Podophyllotoxin* / chemical synthesis
  • Podophyllotoxin* / chemistry
  • Podophyllotoxin* / pharmacology
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents, Phytogenic
  • Podophyllotoxin