Persistent carriage and infection by multidrug-resistant Escherichia coli ST405 producing NDM-1 carbapenemase: report on the first Italian cases

J Clin Microbiol. 2011 Jul;49(7):2755-8. doi: 10.1128/JCM.00016-11. Epub 2011 Apr 27.

Abstract

We report on the first detection of the NDM-1 carbapenemase in Italy, in Escherichia coli isolated in October 2009. Prolonged colonization and relapsing infection by NDM-1-positive E. coli were observed in a patient (index case) with an indirect epidemiological link with areas of endemicity. Transient colonization was apparently observed in another patient linked with the index case.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Carrier State / diagnosis*
  • Carrier State / microbiology
  • DNA, Bacterial / genetics
  • Drug Resistance, Multiple, Bacterial*
  • Electrophoresis, Gel, Pulsed-Field
  • Escherichia coli / classification
  • Escherichia coli / drug effects*
  • Escherichia coli / enzymology*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / diagnosis*
  • Escherichia coli Infections / microbiology
  • Genotype
  • Humans
  • Italy
  • Microbial Sensitivity Tests
  • Molecular Typing
  • Recurrence
  • beta-Lactamases / biosynthesis*

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • beta-Lactamases
  • beta-lactamase NDM-1