Clinical implications of the early detection of urinary microalbumin in diabetic patients using a new high performance liquid chromatography (HPLC) method

Dhammika Gunasekara; Liz Byrnes; Suzanne Brown; John Beilby; Joey Kaye

doi:10.1016/j.diabres.2011.03.035

Clinical implications of the early detection of urinary microalbumin in diabetic patients using a new high performance liquid chromatography (HPLC) method

Diabetes Res Clin Pract. 2011 Aug;93(2):e61-e64. doi: 10.1016/j.diabres.2011.03.035. Epub 2011 Apr 27.

Authors

Dhammika Gunasekara¹, Liz Byrnes², Suzanne Brown³, John Beilby², Joey Kaye³

Affiliations

¹ Department of Nephrology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia. Electronic address: sumuditha@hotmail.com.
² Path West, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia.
³ Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia.

PMID: 21524809
DOI: 10.1016/j.diabres.2011.03.035

Abstract

We assessed urine albumin in 180 diabetics by conventional immunonephelometry (IN) and HPLC methods. Those with HPLC but not IN detectable albuminuria had higher BP, worse glycaemic control and more vascular events (p<0.05 for all) but received fewer vascular risk reduction treatments.

Publication types

Comparative Study
Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Albuminuria / diagnosis*
Blood Glucose
Blood Pressure
Chromatography, High Pressure Liquid / methods*
Chromatography, High Pressure Liquid / standards
Diabetes Mellitus / urine*
Early Diagnosis
Humans
Middle Aged
Nephelometry and Turbidimetry / methods
Nephelometry and Turbidimetry / standards
Vascular Diseases

Substances

Blood Glucose