Abstract
A series of tryptamine derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compounds 2e and 4a showed potent antiviral activity (IC(50)=0.4 and <1 μM, respectively) and low cytotoxicity (CC(50)=40.6 and >25 μM, respectively).
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemistry*
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Antiviral Agents / pharmacology*
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Cell Survival / drug effects
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DNA, Viral / metabolism
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Hep G2 Cells
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Hepatitis B / drug therapy*
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Hepatitis B virus / drug effects*
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Humans
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Structure-Activity Relationship
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Tryptamines / chemistry*
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Tryptamines / pharmacology*
Substances
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Antiviral Agents
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DNA, Viral
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Tryptamines
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tryptamine