Abstract
Recent studies have revealed the important role of aquaporin-1 (AQP1) in tumor cell migration and angiogenesis. However, the function of AQP1 in malignant pleural effusion has not been well characterized. We established a mouse model to examine the role of AQP1 and vascular endothelial growth factor (VEGF) in the development of malignant pleural effusion. We showed that elevated expressions of AQP1 mRNA and VEGF protein were associated with increased volume of malignant pleural effusion. These results suggest that AQP1 and VEGF play important roles in the development of malignant pleural effusion in mice, which may help us find new strategies for the prevention and treatment of malignant pleural effusion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aquaporin 1 / genetics*
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Aquaporin 1 / metabolism*
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism
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Carcinoma, Lewis Lung / genetics
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Carcinoma, Lewis Lung / metabolism
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Carcinoma, Lewis Lung / pathology*
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Immunoenzyme Techniques
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Mice
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Mice, Inbred C57BL
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Pleural Effusion, Malignant / genetics
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Pleural Effusion, Malignant / metabolism
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Pleural Effusion, Malignant / pathology*
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RNA, Messenger / genetics
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Real-Time Polymerase Chain Reaction
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Reverse Transcriptase Polymerase Chain Reaction
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Vascular Endothelial Growth Factor A / genetics*
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Vascular Endothelial Growth Factor A / metabolism*
Substances
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AQP1 protein, human
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Biomarkers, Tumor
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RNA, Messenger
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VEGFA protein, human
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Vascular Endothelial Growth Factor A
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Aquaporin 1