Synthesis and antimicrobial activity of some novel dicationic sulphonophanes

Eur J Med Chem. 2011 Jul;46(7):3093-8. doi: 10.1016/j.ejmech.2011.03.063. Epub 2011 Apr 12.

Abstract

The synthesis of some novel imidazole-based dicationic sulfonophanes incorporating various spacer units is described. All the sulphonophanes exhibit good antibacterial and antifungal activity against five bacterial strains Bacillus subtilis, Staphylococcus aureus, Vibrio cholera, Escherichia coli, Proteus vulgaris and human pathogenic fungus Candida albicans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / pharmacology
  • Bacillus subtilis / drug effects
  • Bacillus subtilis / growth & development
  • Candida albicans / drug effects
  • Candida albicans / growth & development
  • Cations
  • Ciprofloxacin / pharmacology
  • Clotrimazole / pharmacology
  • Escherichia coli / drug effects
  • Escherichia coli / growth & development
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Proteus vulgaris / drug effects
  • Proteus vulgaris / growth & development
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / growth & development
  • Structure-Activity Relationship
  • Sulfones / chemical synthesis*
  • Sulfones / pharmacology
  • Vibrio cholerae / drug effects
  • Vibrio cholerae / growth & development

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Cations
  • Imidazoles
  • Sulfones
  • Ciprofloxacin
  • Clotrimazole