Abstract
The synthesis of some novel imidazole-based dicationic sulfonophanes incorporating various spacer units is described. All the sulphonophanes exhibit good antibacterial and antifungal activity against five bacterial strains Bacillus subtilis, Staphylococcus aureus, Vibrio cholera, Escherichia coli, Proteus vulgaris and human pathogenic fungus Candida albicans.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / pharmacology
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Bacillus subtilis / drug effects
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Bacillus subtilis / growth & development
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Candida albicans / drug effects
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Candida albicans / growth & development
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Cations
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Ciprofloxacin / pharmacology
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Clotrimazole / pharmacology
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Escherichia coli / drug effects
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Escherichia coli / growth & development
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology
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Microbial Sensitivity Tests
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Models, Molecular
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Proteus vulgaris / drug effects
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Proteus vulgaris / growth & development
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
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Structure-Activity Relationship
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Sulfones / chemical synthesis*
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Sulfones / pharmacology
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Vibrio cholerae / drug effects
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Vibrio cholerae / growth & development
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Cations
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Imidazoles
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Sulfones
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Ciprofloxacin
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Clotrimazole