Neuroprotective labdane diterpenes from Fritillaria ebeiensis

Jing Xu; Cuizhou Liu; Ping Guo; Yuanqiang Guo; Da-Qing Jin; Xiaoqiang Song; Zhanping Sun; Liping Gui; Yonggang Ma

doi:10.1016/j.fitote.2011.03.009

Neuroprotective labdane diterpenes from Fritillaria ebeiensis

Fitoterapia. 2011 Jul;82(5):772-6. doi: 10.1016/j.fitote.2011.03.009. Epub 2011 Apr 13.

Authors

Jing Xu¹, Cuizhou Liu, Ping Guo, Yuanqiang Guo, Da-Qing Jin, Xiaoqiang Song, Zhanping Sun, Liping Gui, Yonggang Ma

Affiliation

¹ College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, China.

PMID: 21513776
DOI: 10.1016/j.fitote.2011.03.009

Abstract

By bioactivity-guided isolation, two labdane diterpenes (1 and 2) have been isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated as 6α,7β-dihydroxy-labda-8(17),12(E),14-triene (1) and 6-oxo-2α-hydroxy-labda-7,12(E), 14-triene (2), on the basis of spectroscopic data analysis (IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR). Both of the isolates showed neuroprotective effects against MPP(+)-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Death / drug effects*
Cell Line, Tumor
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Fritillaria / chemistry*
Humans
Neuroprotective Agents / chemistry
Neuroprotective Agents / isolation & purification*
Neuroprotective Agents / pharmacology
Plant Extracts / chemistry*
Plant Roots

Substances

6-oxo-2alpha-hydroxy-labda-7,12(E),14-triene
6alpha,7beta-dihydroxy-labda-8(17),12(E),14-triene
Diterpenes
Neuroprotective Agents
Plant Extracts