Special delivery: granulin brings CpG DNA to Toll-like receptor 9

Eva Marie Y Moresco; Bruce Beutler

doi:10.1016/j.immuni.2011.04.001

Special delivery: granulin brings CpG DNA to Toll-like receptor 9

Immunity. 2011 Apr 22;34(4):453-5. doi: 10.1016/j.immuni.2011.04.001.

Authors

Eva Marie Y Moresco¹, Bruce Beutler

Affiliation

¹ Department of Genetics, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Foreign DNA activates the innate immune response through Toll-like receptor 9 (TLR9). In this issue of Immunity, Park et al. (2011) present evidence that granulin is a cofactor for TLR9 activation, delivering CpG-oligodeoxynucleotides to TLR9 in endolysosomes.

Publication types

Comment

Abstract

Publication types

Grants and funding