Nickel-catalyzed selective defluorination to generate partially fluorinated biaryls

Org Lett. 2011 May 20;13(10):2750-3. doi: 10.1021/ol200860t. Epub 2011 Apr 21.

Abstract

A Ni-catalyzed, chemoselective cross-coupling reaction of polyfluoroarenes under mild reaction conditions is reported. A variety of fluorine-containing biaryls are synthesized in good-to-excellent yields. A wide range of substitution patterns and functional groups are tolerated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Combinatorial Chemistry Techniques
  • Hydrocarbons, Fluorinated / chemical synthesis*
  • Hydrocarbons, Fluorinated / chemistry
  • Molecular Structure
  • Nickel / chemistry*

Substances

  • Hydrocarbons, Fluorinated
  • Nickel