Abstract
Palladium-catalyzed N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol were carried out. The reaction in the presence of Pd(OAc)(2) (5 mol%), sodium diphenylphosphinobenzene-3-sulfonate (TPPMS, 10 mol%), and AcONa (2 equiv) in water at 120 °C for 16 h in a sealed tube gave only mono-N-allylated amino acids in good yield.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Amino Acids / chemistry*
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Catalysis
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Molecular Structure
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Organometallic Compounds / chemistry*
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Palladium / chemistry*
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Propanols / chemistry*
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Stereoisomerism
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Water / chemistry*
Substances
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Amino Acids
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Organometallic Compounds
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Propanols
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Water
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allyl alcohol
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Palladium