Diffuse large B-cell lymphoma carrying both t(3 ; 7)(q27 ; p12) and t(8 ; 14)(q24 ; q32)

Intern Med. 2011;50(8):905-8. doi: 10.2169/internalmedicine.50.4860. Epub 2011 Apr 15.

Abstract

We report a 60-year-old man with diffuse large B-cell lymphoma harboring both t(3 ; 7)(q27 ; p12) and t(8 ; 14)(q24 ; q32). Although he received six courses of conventional combination chemotherapy plus rituximab, early relapse occurred. Four courses of an intensive salvage regimen and high-dose chemotherapy with autologous peripheral blood stem cell transplantation were performed. The patient has remained in complete remission for over 24 months. This case is noteworthy because both genetic abnormalities are implicated in lymphomagenesis.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal, Murine-Derived / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols
  • Chromosomes, Human, Pair 14 / genetics*
  • Chromosomes, Human, Pair 3 / genetics*
  • Chromosomes, Human, Pair 7 / genetics*
  • Chromosomes, Human, Pair 8 / genetics*
  • DNA-Binding Proteins / genetics
  • Genes, myc
  • Humans
  • Ikaros Transcription Factor / genetics
  • Karyotyping
  • Lymphoma, Large B-Cell, Diffuse / genetics*
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Lymphoma, Large B-Cell, Diffuse / therapy
  • Male
  • Middle Aged
  • Oncogene Fusion
  • Peripheral Blood Stem Cell Transplantation
  • Proto-Oncogene Proteins c-bcl-6
  • Remission Induction
  • Rituximab
  • Salvage Therapy
  • Translocation, Genetic*
  • Transplantation, Autologous

Substances

  • Antibodies, Monoclonal, Murine-Derived
  • BCL6 protein, human
  • DNA-Binding Proteins
  • IKZF1 protein, human
  • Proto-Oncogene Proteins c-bcl-6
  • Ikaros Transcription Factor
  • Rituximab