Abstract
We report a 60-year-old man with diffuse large B-cell lymphoma harboring both t(3 ; 7)(q27 ; p12) and t(8 ; 14)(q24 ; q32). Although he received six courses of conventional combination chemotherapy plus rituximab, early relapse occurred. Four courses of an intensive salvage regimen and high-dose chemotherapy with autologous peripheral blood stem cell transplantation were performed. The patient has remained in complete remission for over 24 months. This case is noteworthy because both genetic abnormalities are implicated in lymphomagenesis.
MeSH terms
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Antibodies, Monoclonal, Murine-Derived / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols
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Chromosomes, Human, Pair 14 / genetics*
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Chromosomes, Human, Pair 3 / genetics*
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Chromosomes, Human, Pair 7 / genetics*
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Chromosomes, Human, Pair 8 / genetics*
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DNA-Binding Proteins / genetics
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Genes, myc
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Humans
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Ikaros Transcription Factor / genetics
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Karyotyping
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Lymphoma, Large B-Cell, Diffuse / genetics*
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Lymphoma, Large B-Cell, Diffuse / pathology
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Lymphoma, Large B-Cell, Diffuse / therapy
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Male
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Middle Aged
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Oncogene Fusion
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Peripheral Blood Stem Cell Transplantation
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Proto-Oncogene Proteins c-bcl-6
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Remission Induction
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Rituximab
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Salvage Therapy
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Translocation, Genetic*
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Transplantation, Autologous
Substances
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Antibodies, Monoclonal, Murine-Derived
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BCL6 protein, human
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DNA-Binding Proteins
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IKZF1 protein, human
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Proto-Oncogene Proteins c-bcl-6
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Ikaros Transcription Factor
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Rituximab