Prenylated Polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07

J Nat Prod. 2011 May 27;74(5):1106-10. doi: 10.1021/np2000478. Epub 2011 Apr 12.

Abstract

Six new prenylated polyhydroxy-p-terphenyl metabolites, named prenylterphenyllins A-C (1-3) and prenylcandidusins A-C (5-7), and one new polyhydroxy-p-terphenyl with a simple tricyclic C-18 skeleton, named 4''-dehydro-3-hydroxyterphenyllin (4), were obtained together with eight known analogues (8-15) from Aspergillus taichungensis ZHN-7-07, a root soil fungus isolated from the mangrove plant Acrostichum aureum. Their structures were determined by spectroscopic methods, and their cytotoxicity was evaluated using HL-60, A-549, and P-388 cell lines. Compounds 1 and 8 exhibited moderate activities against all three cell lines (IC50 1.53-10.90 μM), whereas compounds 4 and 6 displayed moderate activities only against the P-388 cell line (IC50 of 2.70 and 1.57 μM, respectively).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Aspergillus / chemistry*
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Inhibitory Concentration 50
  • Leukemia P388
  • Mice
  • Molecular Structure
  • Plant Roots / microbiology
  • Prenylation
  • Rhizophoraceae / microbiology
  • Terphenyl Compounds / chemistry
  • Terphenyl Compounds / isolation & purification*
  • Terphenyl Compounds / pharmacology

Substances

  • Antineoplastic Agents
  • Terphenyl Compounds