Domino reactions for the synthesis of bridged bicyclic frameworks: fast access to bicyclo[n.3.1]alkanes

Chem Soc Rev. 2011 Jul;40(7):3445-54. doi: 10.1039/c1cs15018a. Epub 2011 Apr 11.

Abstract

In the current bid for synthetic efficiency, multiple bond-forming transformations are becoming a key concept in organic synthesis. In this context, domino protocols have become increasingly common in the synthesis of bicyclic systems. This tutorial review aims at providing a short but authoritative overview of this topic, focusing on the preparation of bridged bicyclo[n.3.1]alkane systems, and is organized according to the number of rings created in the key domino process.

Publication types

  • Review

MeSH terms

  • Alkanes / chemistry*
  • Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry*
  • Kinetics
  • Organometallic Compounds / chemistry

Substances

  • Alkanes
  • Bridged Bicyclo Compounds, Heterocyclic
  • Organometallic Compounds