The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase

Cell Res. 2011 Jun;21(6):983-6. doi: 10.1038/cr.2011.66. Epub 2011 Apr 12.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Hypoxia
  • Dioxygenases / genetics
  • Dioxygenases / metabolism*
  • Dioxygenases / pharmacology
  • Drosophila
  • Enzyme Assays
  • Enzyme Inhibitors / metabolism*
  • Enzyme Inhibitors / pharmacology
  • HeLa Cells
  • Humans
  • Hypoxia-Inducible Factor-Proline Dioxygenases
  • Mice
  • Protein Binding
  • Pyruvate Kinase / antagonists & inhibitors
  • Pyruvate Kinase / metabolism*
  • RNA Interference

Substances

  • Enzyme Inhibitors
  • Dioxygenases
  • EGLN3 protein, human
  • Hypoxia-Inducible Factor-Proline Dioxygenases
  • Pyruvate Kinase