Inflammation in nonalcoholic steatohepatitis

Expert Rev Gastroenterol Hepatol. 2011 Apr;5(2):189-200. doi: 10.1586/egh.11.21.

Abstract

Nonalcoholic fatty liver disease (NAFLD) describes a range of disorders characterized by excess accumulation of triglyceride within the liver. While simple steatosis may be clinically stable, nonalcoholic steatohepatitis (NASH) can be progressive. Inflammation is believed to be the driving force behind NASH and the progression to fibrosis and subsequent cirrhosis. This article will review and interpret the current literature in an attempt to expand our understanding of the environmental and genetic causes of inflammation and its effects in NAFLD.

Publication types

  • Review

MeSH terms

  • Abdominal Fat / metabolism
  • Adipokines / metabolism
  • Animals
  • Cytokines / metabolism
  • Fatty Liver / epidemiology
  • Fatty Liver / etiology
  • Fatty Liver / genetics
  • Fatty Liver / metabolism*
  • Fatty Liver / pathology
  • Fructose / metabolism
  • Gastrointestinal Tract / microbiology
  • Hepatitis* / complications
  • Hepatitis* / epidemiology
  • Hepatitis* / genetics
  • Hepatitis* / pathology
  • Humans
  • Inflammation Mediators / metabolism
  • Insulin Resistance
  • Lipid Metabolism
  • Male
  • Mice
  • Muscle, Skeletal / metabolism
  • Non-alcoholic Fatty Liver Disease
  • Oxidative Stress

Substances

  • Adipokines
  • Cytokines
  • Inflammation Mediators
  • Fructose