Abstract
Optimal combination of chlorhexidine bigluconate with ascorbic acid, succinic acid, and zinc oxide was found as a result of comparative trials. The composition shows antioxidative effects and is capable of initiating antibody producing and phagocytosis. This combination can be used as an active substance of orodispersible tablets for the treatment respiratory tract infections.
MeSH terms
-
Administration, Oral
-
Animals
-
Anti-Bacterial Agents / pharmacology*
-
Anti-Bacterial Agents / therapeutic use
-
Antibody Formation
-
Antioxidants / pharmacology*
-
Antioxidants / therapeutic use
-
Ascorbic Acid / chemistry
-
Ascorbic Acid / pharmacology*
-
Ascorbic Acid / therapeutic use
-
Chlorhexidine / analogs & derivatives*
-
Chlorhexidine / chemistry
-
Chlorhexidine / pharmacology
-
Chlorhexidine / therapeutic use
-
Drug Combinations
-
Escherichia coli / drug effects
-
Exudates and Transudates / drug effects*
-
Immunologic Factors / pharmacology*
-
Immunologic Factors / therapeutic use
-
Male
-
Mice
-
Mice, Inbred BALB C
-
Phagocytosis / drug effects
-
Rats
-
Staphylococcus aureus / drug effects
-
Succinic Acid / chemistry
-
Succinic Acid / pharmacology*
-
Succinic Acid / therapeutic use
-
Tablets
-
Zinc Oxide / chemistry
-
Zinc Oxide / pharmacology*
-
Zinc Oxide / therapeutic use
Substances
-
Anti-Bacterial Agents
-
Antioxidants
-
Drug Combinations
-
Immunologic Factors
-
Tablets
-
Succinic Acid
-
chlorhexidine gluconate
-
Ascorbic Acid
-
Chlorhexidine
-
Zinc Oxide