The mortality risk of metabolic disease for psychotic patients is reported to be high. Therefore, in this research, we investigated the compliance with drug therapy among psychotic patients who had diabetes or dyslipidemia. Based on this investigation, we counseled and educated the patients from the pharmaceutical point of view. The effects of pharmaceutical consultation and education were evaluated based on the compliance rate of drug therapy, body mass index (BMI), and blood glucose and cholesterol levels. A significant difference was found between the drug therapy compliance rate and blood glucose level after consultation and education. However, there was no significant difference in the BMI and blood cholesterol level. Our results suggest that patient education is effective in increasing the drug therapy compliance rate and reducing blood glucose levels in psychotic patients.