Citrinin derivatives from the marine-derived fungus Penicillium citrinum

Li Chen; Wei Liu; Xiao Hu; Kai Huang; Jiu-Lin Wu; Qi-Qing Zhang

doi:10.1248/cpb.59.515

Citrinin derivatives from the marine-derived fungus Penicillium citrinum

Chem Pharm Bull (Tokyo). 2011;59(4):515-7. doi: 10.1248/cpb.59.515.

Authors

Li Chen¹, Wei Liu, Xiao Hu, Kai Huang, Jiu-Lin Wu, Qi-Qing Zhang

Affiliation

¹ Institute of Biomedical and Pharmaceutical Technology & College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, P.R. China.

PMID: 21467687
DOI: 10.1248/cpb.59.515

Abstract

Three new citrinin derivatives, penicitrinols C, D, and E (1-3), along with two known compounds, citrinin (4) and decarboxydihydrocitrinone (5), were isolated from Penicillium citrinum. Their structures were determined by spectroscopic methods and X-ray diffraction analysis. Compounds 1 and 3 demonstrated weak cytotoxicity against the HL-60 cell line.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / toxicity
Aquatic Organisms / microbiology*
Citrinin / analogs & derivatives*
Citrinin / chemistry
Citrinin / isolation & purification
Citrinin / toxicity
Crystallography, X-Ray
Molecular Conformation
Penicillium / chemistry*

Substances

Antineoplastic Agents
penicitrinol C
penicitrinol D
penicitrinol E
Citrinin