Although studies have found evidence that certain workplace conditions in North American enterprises may serve as risk factors for alcohol and illicit drug use, little is known regarding the generalizability of these findings to enterprises in other countries. To address this gap, we collected data from a random sample of 569 blue-collar workers employed in nine different facilities of one of Israel's largest manufacturing firms. The results of zero-inflated Poisson and ordered probit regressions partly confirmed earlier findings reported in North America, with a heightened rate of a substance use among those perceiving (a) more permissive drinking norms, (b) lower supervisor ability to handle substance use problems, (c) greater exposure to job hazards, and (d) lower levels of coworker interactions. Permissive drinking norms were also found to moderate the associations between the other risk factors and substance use.