Resin-modified glass ionomer cements have shown their reliability and durability in various applications in young dental patients. The latest generation of these materials, the nano-ionomer, has been introduced, and its improved properties make it an effective alternative for restoring primary and permanent teeth. The purpose of this paper was to describe the properties of the nano-ionomer, provide indications for its use, and illustrate the technique for applying the material. Representative clinical cases are presented.